Effects of dietary lipids on renal function of aged rats.

نویسندگان

  • C Valente Gamba
  • A Zeraib Caraviello
  • A Matsushita
  • G M Alves
  • L Nunes Da Silva
  • G Nascimento Gomes
  • F Zaladek Gil
چکیده

Normal aging is accompanied by renal functional and morphological deterioration and dietetic manipulation has been used to delay this age-related decline. We examined the effects of chronic administration of diets containing 5% lipid-enriched diet (LD, w/w) on renal function of rats at different ages. Three types of LD were tested: canola oil, fish oil and butter. Mean systemic tail-cuff blood pressure and glycemia remained within the normal range whatever the age and the diet of the animals. Proteinuria began to rise from the 8th month in the groups ingesting LD, while in the control group it increased significantly (above 10 mg/24 h) only after the 10th month. With age, a significant and progressive decline in glomerular filtration rate (GFR) and renal plasma flow was observed in the LD groups but after 6 months of lipid supplementation, the decline in these parameters was more marked in the butter and fish oil groups. By the 18th month, the lowest GFR level was observed in the group ingesting the butter diet (2.93 +/- 0.22 vs 5.01 +/- 0.21 ml min(-1) kg(-1) in control, P<0.05). Net acid excretion, evaluated in 9- and 18-month-old rats, was stimulated in the fish oil group when compared both to control and to the other two LD groups. These results suggest that even low levels of LD in a chronic nutritional regimen can modify the age-related changes in renal function and that the impact of different types of lipid-supplemented diets on renal function depends on the kind of lipid present in the diet.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Effect of exogenous leptin on serum levels of lipids, glucose, renal and hepatic variables in both genders of obese and streptozotocin-induced diabetic rats

Objective(s): Leptin exerts various effects on appetite and body weight. Disruption of the obesitygene is precedent to fatness. Insulin or glucose elevates leptin, but streptozotocin reduces it. However, controversial data exist for the effects of leptin on diabetes and leptin level in each gender. Leptin can damage the kidney function but little evidence exists for its hepatic effects. The aim...

متن کامل

Effect of Dietary Ethanolic Extract of Lavandula officinalis on Serum Lipids Profile in Rats

AbstractAntioxidants are effective in prevention and treatment of cardiovascular diseases. Lavandula officinalis possesses antioxidant activity, therefore, in this study, the effects of Lavandula officinalis extract were investigated on serum lipids levels of rats. Experimental mature male Wistar rats were treated with 100, 200 or 400 mg/kg/day of lavender ethanolic extract or distilled water f...

متن کامل

Effect of Dietary Ethanolic Extract of Lavandula officinalis on Serum Lipids Profile in Rats

AbstractAntioxidants are effective in prevention and treatment of cardiovascular diseases. Lavandula officinalis possesses antioxidant activity, therefore, in this study, the effects of Lavandula officinalis extract were investigated on serum lipids levels of rats. Experimental mature male Wistar rats were treated with 100, 200 or 400 mg/kg/day of lavender ethanolic extract or distilled water f...

متن کامل

Effects of Chronic Administration of Different Doses of Nitrate on Renal Function in Female Rats

Introduction: As a nitric oxide (NO) donor, nitrate administration improves renal function in male animals. This study aims to determine the effects of chronic administration of different doses of nitrate on kidney function in normal adult female rats by measuring serum urea and creatinine and assessing the estimated glomerular filtration rate (eGFR). Materials and Method: Two-month old female ...

متن کامل

Renal Effects of Anchomanes difformis Crude Extract in Wistar Rats

Objective:  Anchomanes difformis is a member of the plant family Araceae which is used as a diuretic but also has other medicinal applications. This study investigates the dietary effects of A. difformis on the kidneys of adult wistar rats. Materials and Methods: Sixteen rats were used and were weighed, before and after the experiment. All rats were randomly divided into four groups. All groups...

متن کامل

Effect of dietary virgin olive oil on serum lipids levels in rats

Background: Relationship between olive oil consumption and low cardiovascular mortality and mobility is the aim of current study. We were investigated of dietary virgin olive oil (VOO) effects on serum lipids profile. Methods: Experimental mature male rats were treated with VOO for 30 days at 0.25, 0.5 and 0.75 ml/kg/day and control group treated with saline at the same time via gastric gava...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas

دوره 34 2  شماره 

صفحات  -

تاریخ انتشار 2001